Details for: MESNA FOR INJECTION
Company: FRESENIUS KABI CANADA LTD
| DIN | DIN name | Active Ingredient(s) | Strength | Dosage Form | Route of Administration |
|---|---|---|---|---|---|
| 02244931 | MESNA FOR INJECTION | MESNA | 100 MG / ML | SOLUTION | INTRAVENOUS |
Consumer Information
This information was provided by the drug’s manufacturer when this drug product was approved for sale in Canada. It is designed for consumers and care givers. It is a summary of information about the drug and will not tell you everything about the drug. Contact your doctor or pharmacist if you have any questions about the drug.
What the medication is used for
Mesna for Injection is used for the reduction and prevention of bleeding in the bladder (hemorrhagic cystitis) caused by anticancer drugs such as cyclophosphamide and ifosfamide
What it does
Mesna for Injection helps to protect the lining of the bladder against damage from anti-cancer drugs. The body breaks down anti-cancer drugs to form products that can harm the bladder. Mesna for Injection works by making these breakdown products less harmful.
When it should not be used
Mesna for Injection should not be used if: You have a known allergy to mesna, any thiol-containing compound or to any of the nonmedicinal ingredients in particular benzyl alcohol.
What the medicinal ingredient is
Mesna
What the non-medicinal ingredients are
Edetate Disodium, Sodium Hydroxide,
What dosage form it comes in
Mesna for Injection is available as 100 mg / mL in 10 mL multiple-dose vials.
Warnings and precautions
BEFORE you use Mesna for Injection, talk to your doctor or pharmacist if:
- You have any allergies to this drug or other drugs similar to mesna, such as amifostine, penicillamine and captopril, or to any of its ingredients.
- You are scheduled to undergo urine screening tests.
- You are pregnant or planning to become pregnant.
- You are nursing an infant.
- You plan to drive or operate machinery.
- You have had previous reactions to mesna.
Interactions with this medication
There are no known drug-drug interactions with Mesna for Injection
Proper use of this medication
Usual Dose
Your doctor will determine what dose of Mesna for Injection
is right for you and how often you should receive it.
Mesna can be taken intravenously or orally.
Mesna for Injection is available in 100 mg / mL for intravenous
use only. Not for other routes of administration.
Overdose
A specific antidote for mesna is not known.
Missed Dose
If you miss your scheduled treatment, contact your doctor or nurse as soon as possible to schedule your next treatment.
Side effects and what to do about them
Because Mesna for Injection is used in combination with other
chemotherapy drugs, it is often difficult to distinguish side
effects that may be caused by mesna from those caused by
other drugs.
If you notice any changes in the way you feel during or after
the treatment, tell your doctor or another member of your
medical team immediately.
Like all medicines, mesna can cause side effects although not
everybody gets them.
The following side effects may happen with this medicine:
Very common (affects more than 1 in 10 people):
- Headache
- Reactions at the application site
- Abdominal pain (colic)
- Feeling abnormally sleepy during the day
- Lightheadedness
- Fever
- Skin rash
- Diarrhea
- Nausea
- Flushing
- Flu-like symptoms (e.g., sore throat, fever, chills, shivering, cough, body aches)
Mesna for Injection can cause serious side effects. These include severe skin rash and skin reactions that can cause death. These problems may occur any time during treatment, but more commonly occur during or after a first treatment or after several weeks of treatment with Mesna. Sometimes the first skin reaction occurs only after several months of treatment.
| Symptom / effect | Talk with your doctor, nurse, or pharmacist only if severe | Talk with your doctor, nurse, or pharmacist in all cases |
|---|---|---|
Skin rash caused by a reaction to
drugs that includes the following
symptoms:
|
✔ | |
| Red or inflamed eyes like “pink eye” (conjunctivitis) | ✔ | |
| Liver problems | ✔ | |
| Chest pain, rapid heart beat | ✔ | |
| Breathing difficulties | ✔ | |
| Feeling unwell or like you have the flu. | ✔ | |
| Tiredness | ✔ | |
| Severe dizziness | ✔ |
This is not a complete list of side effects. For any unexpected effects while taking Mesna for Injection, contact your doctor or pharmacist.
How to store
Store the vials at 15 °C to 30 °C. Keep out of reach and sight of children.
Reporting side effects
Reporting Side Effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
- Visiting the Web page on Adverse Reaction Reporting (https://www.canada.ca/en/healthcanada/services/drugs-health-products/medeffectcanada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
- Calling toll-free at 1-866-234-2345.
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.
More information
If you want more information about Mesna for Injection:
- Talk to your healthcare professional
- Find the full product monograph that is prepared for health professionals and includes this Consumer Information by visiting the Health Canada website (https://health-products.canada.ca/dpd-bdpp/index-eng.jsp); Fresenius Kabi Canada’s website (http://www.fresenius-kabi.com/en-ca/), or by calling 1-877-821-7724.
Fresenius Kabi Canada Ltd.
165 Galaxy Blvd, Suite 100
Toronto, ON M9W 0C8
Last Revised: July 30, 2019