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Details for: CEFAZOLIN FOR INJECTION, USP

Company: FRESENIUS KABI CANADA LTD

DIN DIN name Active Ingredient(s) Strength Dosage Form Route of Administration
02237138CEFAZOLIN FOR INJECTION, USPCEFAZOLIN (CEFAZOLIN SODIUM)1.0 G / VIALPOWDER FOR SOLUTIONINTRAMUSCULAR
02237138CEFAZOLIN FOR INJECTION, USPCEFAZOLIN (CEFAZOLIN SODIUM)1.0 G / VIALPOWDER FOR SOLUTIONINTRAVENOUS
02237140CEFAZOLIN FOR INJECTION, USPCEFAZOLIN (CEFAZOLIN SODIUM)10 G / VIALPOWDER FOR SOLUTIONINTRAVENOUS
02401029CEFAZOLIN FOR INJECTION, USPCEFAZOLIN (CEFAZOLIN SODIUM)100 G / BAGPOWDER FOR SOLUTIONINTRAVENOUS
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Summary Reports

Summary Safety Review - Beta-lactam antibiotics - Assessing the potential risk of severe skin side effects

Consumer Information

This information was provided by the drug’s manufacturer when this drug product was approved for sale in Canada. It is designed for consumers and care givers. It is a summary of information about the drug and will not tell you everything about the drug. Contact your doctor or pharmacist if you have any questions about the drug.

What the medication is used for

Cefazolin for Injection, USP is used for the treatment of infections caused by certain bacteria in many different parts of the body including the treatment of pneumonia.

Cefazolin for Injection, USP can also be used to prevent infections, before and after surgery.

Antibacterial drugs like Cefazolin for Injection, USP treat only bacterial infections. They do not treat viral infections.

What it does

Cefazolin for Injection, USP is an antibiotic, which belongs to a class of drugs called cephalosporins. Cefazolin for Injection, USP works by killing bacteria which cause infections in the body.

When it should not be used
  • you have had an allergic reaction to Cefazolin for Injection, USP or other medicines such as cephalosporins.
What the medicinal ingredient is

cefazolin sodium

What the non-medicinal ingredients are

none

What dosage form it comes in
  • 15 mL vials containing cefazolin sodium equivalent to 500 mg of cefazolin, packaged 25 vials per carton.
  • 15 mL vials containing cefazolin sodium equivalent to 1 g of cefazolin, packaged 25 vials or 10 vials per carton.
  • 100 mL vials containing cefazolin sodium equivalent to 500 mg of cefazolin, packaged 10 vials per carton.
  • 100 mL vials containing cefazolin sodium equivalent to 1 g of cefazolin, packaged 10 vials per carton.
  • 100 mL “Pharmacy Bulk Package” vials containing cefazolin sodium equivalent to 10 grams of cefazolin, packaged 10 vials per carton.
  • 100 mL “Pharmacy Bulk Vials” containing cefazolin sodium equivalent to 20 grams of cefazolin, packaged 10 vials per carton.
  • 100 grams SmartPak® “Pharmacy Bulk Package” containing cefazolin sodium equivalent to 100 grams of cefazolin.
Warnings and precautions

To help avoid side effects and ensure proper use, talk to your healthcare professional before you take Cefazolin for Injection, USP. Talk about any health conditions or problems you may have, including if you:

  • have had an allergic reaction to penicillins
  • have a history of bowel disease, particularly colitis
  • have gallbladder problems
  • have kidney problems with or without liver problems
  • are pregnant or could become pregnant during treatment
  • are breast feeding

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.

Interactions with this medication

  • Probenecid used in the treatment of gout
Proper use of this medication
  • Cefazolin for Injection, USP will be given to you by your healthcare professional as an injection into either a vein or a muscle.
  • Although you may feel better early in treatment, Cefazolin for Injection, USP should be used exactly as directed.
  • Misuse or overuse of Cefazolin for Injection, USP could lead to the growth of bacteria that will not be killed by Cefazolin for Injection, USP (resistance). This means that Cefazolin for Injection, USP may not work for you in the future.
  • Do not share your medicine.

Usual Dose

Your healthcare professional will decide how much Cefazolin for Injection, USP to give you and how often.

Overdose

If you think you have been given too much Cefazolin for Injection, USP, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms.

Missed Dose

If you miss an appointment to receive an injection of Cefazolin for Injection, USP, contact your healthcare professional as soon as possible.

Side effects and what to do about them

These are not all the possible side effects you may feel when taking Cefazolin for Injection, USP. If you experience any side effects not listed here, contact your healthcare professional.

Side effects may include:

  • diarrhea, nausea, vomiting
  • stomach cramps, loss of appetite
  • rash, itching
  • pain, tenderness or a hardened mass at the injection site
  • vaginal and anal itching

Cefazolin for Injection, USP can cause abnormal blood test results. Your healthcare professional will decide when to perform blood tests and interpret the results.

Serious side effects and what to do about them
Symptom / effect Talk to your healthcare professional Only if severe Talk to your healthcare professional In all cases Stop taking drug and get immediate medical help
Anemia: fatigue, loss of energy, weakness, shortness of breath    
Hypersensitivity: rash, hives, swelling of the face, lips, tongue or throat, difficulty swallowing or breathing    
Liver disorder: yellowing of the skin or eyes, dark urine, abdominal pain, nausea, vomiting, loss of appetite    
Oral candidiasis (yeast infection): creamy white bumps on the tongue, cheeks, gums or throat that bleed when scraped, pain, trouble swallowing, bad taste in the mouth    
Phlebitis: swelling of a vein near the injection site, with pain, tenderness, redness    
Platelet count increased: burning, redness, throbbing, numbness and/or tingling in the hands and feet, headache, dizziness, weakness, fainting, chest pain, vision changes    
Pseudomembranous colitis: watery, bloody diarrhea, mucus in the stool, abdominal cramps and pain, fever    
Vulvovaginal mycotic infection: vaginal itching, burning during intercourse or urination, pain, redness, swelling, discharge    
White blood cell count decreased: infection, fatigue, fever, aches, pain, flu-like symptoms    

If you have a troublesome symptom or side effect that is not listed here or becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

How to store

Cefazolin for Injection, USP (unreconstituted product) in vials should be stored between 15 °C and 30 °C and protected from light.

Cefazolin for Injection, USP in SmartPak® bag: Prior to reconstitution, store dry powder between 15 °C and 25 °C. PROTECT FROM LIGHT. THE INNER BAG SHOULD BE RETAINED IN THE OUTER BAG UNTIL TIME OF USE.

Keep out of reach and sight of children.

Reporting side effects

You can report any suspected side effects associated with the use of health products to Health Canada by:

NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.

More information
  • Talk to your healthcare professional
  • Find the full product monograph that is prepared for healthcare professionals and includes this Patient Medication Information by visiting the Health Canada website (https://www.canada.ca/en/health-canada.html); Fresenius Kabi Canada’s website (http://www.fresenius-kabi.com/en-ca/), or by calling 1-877-821-7724.

This leaflet was prepared by:

Fresenius Kabi Canada Ltd.
165 Galaxy Blvd, Suite 100
Toronto, ON M9W 0C8

Last revised: December 14, 2018

Date modified: