Details for: SUPRANE
Company: BAXTER CORPORATION
| DIN | DIN name | Active Ingredient(s) | Strength | Dosage Form | Route of Administration |
|---|---|---|---|---|---|
| 02227428 | SUPRANE | DESFLURANE | 100 % / V/V | LIQUID | INHALATION |
Summary Reports
Consumer Information
This information was provided by the drug’s manufacturer when this drug product was approved for sale in Canada. It is designed for consumers and care givers. It is a summary of information about the drug and will not tell you everything about the drug. Contact your doctor or pharmacist if you have any questions about the drug.
What the medication is used for
SUPRANE is an inhaled general anesthetic used during surgery.
What it does
SUPRANE maintains unconsciousness, muscle relaxation, and loss of sensation over the entire body while surgery is being performed.
When it should not be used
- If you have been told that you are allergic to desflurane or other inhaled general anesthetics, or components of the container.
- If you have a history of liver inflammation (hepatitis) due to the use of an inhaled general anesthetic, or have experienced unexplained liver problems (for example jaundice with fever) after a previous use of an inhaled general anesthetic.
- If you or any member of your family has experienced a condition called malignant hyperthermia (a genetic disorder that causes rapid raise in body temperature) during an operation.
What the medicinal ingredient is
Desflurane, USP.
What the non-medicinal ingredients are
The finished product is composed solely of the active ingredient, desflurane, USP.
What dosage form it comes in
SUPRANE is available as a volatile liquid that is 100% v/v in concentration.
Warnings and precautions
Serious Warnings and Precautions
- SUPRANE should only be administered by qualified individuals trained in general anesthesia in an adequately equipped facility;
- SUPRANE may trigger a rise in blood potassium or body temperature. You may experience stiff muscles, changes in blood pressure, rapid breathing, a bluish colour to lips or fingers, rapid or irregular heart rate. Trained health care professionals will take care of you if this happens.
You should talk to your anaesthesia professional prior to surgery if you are aware of any of the following conditions:
- If you have been told that you are allergic to desflurane or other inhaled general anesthetics, or components of the container.
- You are pregnant or could be pregnant.
- You are breast-feeding.
- You are taking or have recently taken any other medicines, even those not prescribed.
- You have previously had general anesthesia, particularly if repeated over a short period of time.
- You are suffering from any illness, other than those connected with your operation, such as diabetes, severe headaches, cancer, problems with your nerves or muscles (especially muscular dystrophy), nausea or vomiting.
- You or a member of your family suffers from malignant hyperthermia (a genetic disorder that causes rapid raise in body temperature).
- You suffer from a heart, liver, or kidney problem.
- If your child who needs anesthetics has asthma or has recently had an upper respiratory (airway) infection.
Recovery of consciousness following SUPRANE administration generally occurs within minutes. As with other anesthetics, small changes in moods may persist for several days following administration.
Performance of activities requiring mental alertness, such as operating a motor vehicle or hazardous machinery, may be impaired for some time after general anesthesia. Do not drive a motor vehicle or operate hazardous machinery for at least 24 hours after having a general anesthetic.
Interactions with this medication
Serious Drug Interactions
- Tell your healthcare professional if you have muscular diseases (especially muscular dystrophy), and:
- You are taking potassium, and/or
- You have heart problems, especially irregular heart beats
Tell your doctor, nurse or pharmacist about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.
Drugs that may interact with SUPRANE include:
Other anesthetics, tranquillizers (e.g. benzodiazepines) and narcotics (e.g. opioids), nitrous oxide gas, muscle relaxants (e.g. pancuronium), beta blockers (e.g. to treat high blood pressure), Monoamine Oxidase Inhibitors (MAO) inhibitors (e.g. to treat depression) and indirect-acting sympathomimetics (e.g. amphetamines, stimulants and appetite suppressants).
Proper use of this medication
Usual dose
Your anesthetist will decide what dose of SUPRANE you will receive. The dose will vary depending on your age, weight, and the type of operation that you are having.
You will receive another anesthetic to make you go to sleep before receiving SUPRANE by inhalation.
Overdose
This will be handled by the anesthetist.
Side effects and what to do about them
Side effects include headache, cough, nausea, vomiting, and excessive production of saliva.
| After exposure to SUPRANE, you should contact your physician or anesthesia professional if you have any of the following reactions: |
|---|
| Agitation
Difficulty breathing/choking/shortness of breath, wheezing Decreased oxygen in your blood: shortness of breath, bluish colour to lips or fingers. Elevated Rise in Blood Glucose, if measured Heart Attack High or low Blood Pressure Bleeding Slow, rapid or irregular Heartbeat Dizziness Jaundice: yellow colour to skin and eyes, dark urine Mild to Severe Allergic reactions Rash, hives, severe itching Severe muscle pain or sore throat Sudden fever with stiffness, pain and weakness in your muscles |
This is not a complete list of side effects. For any unexpected effects while taking SUPRANE, contact your doctor or pharmacist.
How to store
SUPRANE should only be administered in an adequately equipped facility. SUPRANE must be kept out of reach and sight of children. It is stored at or below 30°C (86°F).
Reporting side effects
You can report any suspected side effects associated with the use of health products to Health Canada by:
- Visiting the Web page on Adverse Reaction Reporting (www.canada.ca/en/health-canada/services/drugs-health-products/medeffect-canada/adverse-reaction-reporting.html) for information on how to report online, by mail or by fax; or
- Calling toll-free at 1-866-234-2345.
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.
More information
This document plus the full product monograph, prepared for health professionals can be obtained by contacting the sponsor, Baxter Corporation, at 1-888-719-9955.
This leaflet was prepared by Baxter Corporation, Mississauga, Ontario, L5N 0C2.
Baxter and Suprane are registered trademarks of Baxter International Inc.
Last revised: January 23, 2018