Details for: CYANOKIT
Company: SERB S.A.
| DIN | DIN name | Active Ingredient(s) | Strength | Dosage Form | Route of Administration |
|---|---|---|---|---|---|
| 02375370 | CYANOKIT | HYDROXOCOBALAMIN | 5 G / VIAL | POWDER FOR SOLUTION | INTRAVENOUS |
Consumer Information
This information was provided by the drug’s manufacturer when this drug product was approved for sale in Canada. It is designed for consumers and care givers. It is a summary of information about the drug and will not tell you everything about the drug. Contact your doctor or pharmacist if you have any questions about the drug.
What the medication is used for
Cyanokit is an emergency treatment (antidote) used in patients with known or suspected cyanide poisoning. Cyanide is a highly poisonous chemical. Cyanide poisoning can happen from:
- breathing smoke from household and industrial fires
- breathing or swallowing cyanide
- having your skin exposed to cyanide
What it does
The active ingredient in Cyanokit, hydroxocobalamin, binds to cyanide that is present in the blood, making it less toxic. The complexed cyanide is then renally excreted from the body.
What the medicinal ingredient is
hydroxocobalamin
What the non-medicinal ingredients are
Cyanokit contains hydrochloric acid which is included to help maintain the correct pH of the reconstituted solution.
What dosage form it comes in
Cyanokit (5 g) consists of one vial, containing 5 g hydroxocobalamin powder which is then reconstituted in 200mL of liquid for intravenous administration.
Warnings and precautions
Serious side effects may include:
- allergic reactions. Signs of a serious allergic reaction include chest tightness, trouble breathing, swelling, hives, itching, and a rash
- kidney failure : less urine than usual, kidney damage, crystals in urine.
- increased blood pressure
BEFORE you are administered Cyanokit, talk to your doctor or pharmacist:
- If you are allergic to hydroxocobalamin or vitamin B12. They will have to take this into account before treating you with Cyanokit.
- If you are pregnant. Cyanokit can be administered during pregnancy. Tell your doctor as soon as possible if you were pregnant or think you may have been pregnant during treatment with Cyanokit.
- If you are breastfeeding. However, Cyanokit can be administered during breast feeding. You will be recommended to stop breastfeeding after treatment with Cyanokit.
AFTER you are administered Cyanokit, tell your doctor or pharmacist:
- That you have been treated with Cyanokit if you need to have any blood or urine tests. Cyanokit may modify the results to these tests.
- If you are pregnant of become pregnant after Cyanokit treatment as the product remains in the body for some time and may harm the fetus.
- Women of childbearing age: your doctor will recommend you to practice adequate methods of contraception following Cyanokit treatment.
- If you later suffer a skin burn within 2 weeks of administration of Cyanokit and are being assessed by a healthcare professional (HCP), tell the HCP that you have taken Cyanokit, a product which can cause the skin to redden and interfere with the burn assessment.
Be cautious when using Cyanokit with other cyanide antidotes, since the safety of such combined treatment is not known. If the decision is made to administer another cyanide antidote with Cyanokit, these drugs must not be administered concurrently in the same intravenous lines.
Interactions with this medication
No drug interactions studies have been performed for Cyanokit. However, treatment with Cyanokit can interfere with certain laboratory tests for up to 48 hours after treatment. Treatment with Cyanokit may lead to accidental shut down of haemodialysis machines due to the deep red colour given to the blood plasma by the product. A safety feature in the machine may recognize the deep red colour as failure in the system and shut down.
Proper use of this medication
Usual Adult dose
Cyanokit (5 g dose) after reconstitution is administered through a vein (intravenous or IV) over 15 minutes by an emergency care provider or doctor. A second 5 g dose may be given to you if needed.
Overdose
Side effects and what to do about them
Side effects with Cyanokit may include:
- red coloured urine
- red coloured skin and mucous membranes, acne like rash
- nausea, vomiting, diarrhea, bloody stools, trouble swallowing, stomach pain
- throat tightness, dry throat
- headache, dizziness, memory problems, restlessness
- infusion site reaction
- eye swelling, irritation, or redness
- swelling of feet and ankles
- irregular heart heat, increased heart rate
- fluid in lungs
- kidney damage.
After treatment with Cyanokit:
- Skin redness may last up to 2 weeks. Avoid sun exposure while your skin is red. Urine redness may last up to 5 weeks.
- An acne-like rash may appear 7 to 28 days after treatment with Cyanokit. This rash usually goes away without any treatment.
- Talk to your doctor if you breastfeed. Cyanokit may pass into your breast milk and your doctor will recommend you to stop breastfeeding.
Talk to your doctor about any side effect that bothers you or that does not go away.
| Symptom / effect | Talk with your doctor or pharmacist Only if severe | Talk with your doctor or pharmacist In all cases | Stop taking drug and call your doctor or pharmacist |
|---|---|---|---|
| Common | |||
| Increased Blood Pressure | ✔ | ||
| Unknown | |||
| Kidney failure (signs may include : less urine than usual, kidney damage, crystals in urine) | ✔ | ||
| Uncommon | |||
| Allergic reaction (signs may include swelling, breathing difficulties, skin redness, urticaria (hives) or itching) | ✔ | ||
How to store
Store Cyanokit at 25 ºC; excursions permitted to 15-30ºC.
Once reconstituted, the solution can be stored for up to 6 hours at
a temperature between 2ºC and 40ºC. Discard any unused portion
after 6 hours.
Keep out of reach of children.
Reporting side effects
You can report any suspected side effects associated with the use of health products to Health Canada by :
- Visiting the Web page on Adverse Reaction Reporting (www.canada.ca/en/health-canada/services/drugs-health-products-/medeffect-canada.html) for information on how to report online, by mail or by fax; or
- Calling toll-free at 1-866-234-2345
NOTE: Contact your health professional if you need information about how to manage your side effects. The Canada Vigilance Program does not provide medical advice.
More information
This document plus the full product monograph, prepared for
health professionals can be found at:
webprod.hc-sc.gc.ca/dpd-bdpp/index-eng.jsp or by contacting the distributor, Methapharm Inc., at 1-800-287-7686
(Drug Information).
This leaflet was prepared by Methapharm Inc. for SERB S.A.
Last revised: February 1, 2018