Details for: ALOXI

• you have any heart disorder, including an irregular heartbeat, prolongation of the QT interval or a family history of QT prolongation or sudden cardiac death at less than 50 years of age.
• you have low levels of potassium or magnesium.
• you have high blood pressure.
• you have liver or kidney problems.
• you have acute bowel obstruction or a history of repeated constipation.
• you are pregnant or are planning to become pregnant.
• you are breast-feeding or plan to breast-feed.
• you are allergic to other 5-HT3 receptor antagonists such as ondansetron, dolasetron, or granisetron.

Other warnings you should know about:

Serotonin Syndrome:
A rare but potentially life-threatening reaction that can occur with “antiemetic” medicines such as ALOXI. It can cause serious changes in how your brain, muscles and digestive system work.

Serotonin Syndrome symptoms include:

• fever, sweating, shivering, diarrhea, nausea, vomiting;
• muscle shakes, jerks, twitches or stiffness, overactive reflexes, loss of coordination;
• fast heartbeat, changes in blood pressure;
• confusion, agitation, restlessness, hallucinations, mood changes, unconsciousness, and coma.

The reaction is more likely to occur if you also take certain other medications or herbal products. Be sure to tell your healthcare professional all the medicines and natural health products (such as St. John’s Wort) you are taking.

ALOXI may cause severe allergic reaction. Symptoms include swelling of the face, lips or tongue, difficulty breathing, rash, or fainting.

Do not take ALOXI if you are less than 18 years.

Tell your healthcare professional about all the medicines you take, including any drugs, vitamins, minerals, natural supplements or alternative medicines.